They'll all have their sights set to capture this prestigious event, so let's take a look at a few players who have the best shot of walking away with the trophy.
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Steve Stricker, the 45-year-old veteran, will be a formidable threat at the Memorial Tournament this week. Having won here last year, Stricker is looking for two in a row at the home of the Golden Bear.
With a win under his belt already, Stricker should have some confidence heading into this week's event. Even though Stricks has not played particularly well after his early win, don't write him off just yet.
With his superb driving accuracy and touch in his short game, expect Stricker to hang around the top and perhaps capture another win in 2012.
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With his recent victory at the BMW PGA Championship in Europe, Luke Donald has re-secured his World No. 1 ranking and is looking to capture another title here on American soil.
With his consistency on the course, Donald should be another formidable opponent to watch out for this week.
Donald's superb putting will keep him lurking near the top of the leaderboard and hopefully give him a chance to win.
Besides, with a few wins already, Donald should have plenty of confidence to play well this week and capture the Memorial Tournament.
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Back in 2009, Tiger Woods won the Arnold Palmer Invitational following his knee surgery in 2008. His win at the King's place redefined him as the champion, and he would go on to win five more times that year.
One of Wood's five victories came at the Memorial Tournament, where he battled Jim Furyk down the stretch to capture another title.
Now, it's 2012, and Woods won again at the Arnold Palmer Invitational a few months ago. Though he has struggled the past few weeks, Woods will tee it up at Muirfield Village once again.
If Woods has fixed his swing and is truly back, then perhaps history can repeat itself and Tiger will win the Memorial Tournament once more, just like he did in 2009.
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Bubba Watson, newly-crowned Masters champion, will tee it up this week at the Memorial Tournament.
After his electrifying win at Augusta National, Watson has redefined himself as a golfer.
He now has his eyes set on the Memorial Tournament, and with a major championship under his belt, Watson should have plenty of confidence heading into the venue.
Of course, Watson is a wild card pick and is a little unpredictable sometimes. However, with his long driving off the tee, it's always fun watching Bubba play golf. Let's see if he can play "Bubba" golf this week and walk away with a win.